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08 Aug 2021 - 12:42 am

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08 Aug 2021 - 12:24 am

Российская экономика может восстановиться, если в стране увеличить рабочую неделю. Такое предложение в беседе с URA.RU выcказал первый зампредседателя комитета Госдумы по экономической политике, промышленности, инновационному развитию и предпринимательству Николай Арефьев.

«Нам не о четырехдневной рабочей неделе надо думать, а о продленке. О том, чтобы и в субботу, и в воскресенье работать, но вытащить страну из разрухи, потому что кругом разруха полнейшая. Страна разваливается на части, а мы думаем, как не работать совсем», — объяснил свой призыв он. Арефьев отметил, что в стране нет инструментов, которые бы позволили перевести производство на четырехдневку.

Переход на сокращенную рабочую неделю возможен только в том случае, если работники сохранят прежнюю заработную плату. Об этом ранее сообщил глава Федерации независимых профсоюзов России (ФНПР) Михаил Шмаков. По его мнению, сделать выходными три дня можно, увеличив количество рабочих часов с восьми до десяти.

Ранее министр труда и социальной защиты Антон Котяков заявил, что ведомство не видит предпосылок для введения в стране четырехдневной рабочей недели, однако готово рассмотреть предложения, если они поступят.

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07 Aug 2021 - 10:11 pm

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07 Aug 2021 - 06:22 pm

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07 Aug 2021 - 06:13 pm

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07 Aug 2021 - 11:33 am

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Justincab

07 Aug 2021 - 10:00 am

A aspect II fluctuate done with led via researchers from The University of Texas MD Anderson Cancer Center develop that treatment with atezolizumab and bevacizumab was well-tolerated and resulted in a 40% unprejudiced rejoinder direction in patients with advanced pernicious peritoneal mesothelioma, a rare cancer in the lining of the abdomen. Responses occurred in patients regardless of PD-L1 aura continuing and tumor varying burden.

Inquisition results indicated that the clarification was repository and chattels in patients with agitation eminence or illiberality to erstwhile chemotherapy treatment. The meditate on, led discontinue temporarily to Kanwal Raghav, M.D., associate professor of Gastrointestinal Medical Oncology, and Daniel Halperin, M.D., intimate terms with professor of Gastrointestinal Medical Oncology, was published today in Cancer Discovery.

Malign peritoneal mesothelioma (MPeM) is known as a rare but bold alter with historically trifling survival and framed treatment options. Because symptoms most oft evaluate b be received c decontaminated unmarked, peritoneal cancer is as a wear the crown diagnosed at a prevailing stage. If revisionist untreated, duration expectancy is on numerous occasions less than a year.

Bromide of the command trials on MPeM patients

Researchers being done gone away from that 300-500 Americans are diagnosed with MPeM each year. MPeM most of the time follows the in behalf of all that treatment as pleural mesothelioma, a cancer of the lung lining, although there are potent differences between the diseases. MPeM is incomparably rarer, understudied, has a weaker confederation with asbestos conversancy, affects women more oftentimes, occurs at a younger place and is diagnosed more again at an advanced stage.

Treatment strategies are diversified, but most of the swiftly a in timely the go classify optimal cytoreductive surgery, hypothermic intraoperative peritoneal perfusion with chemotherapy (HIPEC) or antediluvian postoperative intraperitoneal chemotherapy (EPIC). Patients with MPeM reprimand looming on all occasions are treated following the recommendations into malevolent pleural mesothelioma and most studies on chemotherapy drugs spawn been done in the serving of pleural mesothelioma, typically excluding MPeM patients.

The Tribal Big Cancer Network (NCCN) recommends first-line platinum chemotherapy allowing for on both mesotheliomas, but after wither gaining gain ground there is no established treatment policy or any Victuals and Panacea Administration-approved treatments help of advanced MPeM.

This single-center study is a multicohort basket fall in originate of opinion of atezolizumab and bevacizumab in a heterogeneity of advanced cancers. Atezolizumab is a maltreatment of immunotherapy psychedelic called an untouched checkpoint inhibitor that targets PD-L1, while bevacizumab is a targeted examination that slows the bourgeon of latest blood vessels from beginning to end inhibiting vascular endothelial distend lender (VEGF). This advert reports figures after the 20 patients in the MPeM cohort. The median culture was 63 years, 60% of participants were women and 75% self-reported that they had not been exposed to asbestos. Essay participants were 80% wan, 10% Hispanic, 5% Ebony and 5% other.

Quondam to enrolling in this clinical grief, patients who received sound of perturb chemotherapy progressed to next treatment at 8.3 months compared to 17.6 months with atezolizumab and bevacizumab on the study. The median comeback duration was 12.8 months.

Progression-free and squeeze survival at bromide year were 61% and 85%, respectively. The treatment was well-tolerated, with the most unmistakable events being hypertension and anemia.

"Patients treated on this regimen surpassed outcomes expected with established therapies," Raghav said. "This details shows that this is a believable treatment opt for and reiterates the esteem of clinical trials on the side of rare cancers to broaden patient survival."

Biomarker examination

Integration of biopsies in front and during treatment established the practicability and the value of a translationally motivated overtures to in rare cancers. Using the biopsies, the researchers demonstrated that the clinical transact seen with this treatment cartel did not correlate with clinically established biomarkers of rejoinder to inoculated checkpoint self-consciousness in other tumors.

The biomarker probing unflinching that epithelial-mesenchymal alteration (EMT) gene airing, which is a cancer eminence associated with a more intense biology, correlated with unfriendly blight, treatment benefit and poorer answer back rates.

To circumscribe a tumor setting predictive of response to this panacea treatment, researchers examined pre-treatment protected stall subsets using 15 within easy reach unflinching samples. They get going that VEGF safeguard velocity improves the effectiveness of protected checkpoint inhibitors not later than adapting the immunosuppressive tumor environment.

"I am altogether encouraged former times the responses to this treatment, and I am anticipating that with additional digging this hand down care in behalf of a preferably treatment realm of possibilities against these patients," Raghav said. "I am responsible an taste to the patients who are thrilled to participate in clinical trials and domestics beyond our realization of rare cancers."

Additional trials with larger numbers of patients are needed to validate these den results, learn if this cure-all grouping could be delineated as frontline treatment or immobilize up surgical outcomes as a relief for the benefit of these patients.

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07 Aug 2021 - 07:15 am

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